A Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology

A Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology

www.ncbi.nlm.nih.gov

National Center for Biotechnology Information, U.S. National Library of Medicine 8600 Rockville Pike, Bethesda MD, 20894 USA

It is noteworthy that THC is a considerably more effective inhibitor of
AChE-induced Aβ deposition than the approved drugs for Alzheimer's
disease treatment, donepezil and tacrine, which reduced Aβ aggregation
by only 22% and 7%, respectively, at twice the concentration used in our
studies.7
... Therefore, AChE inhibitors such as THC and its analogues may provide an
improved therapeutic for Alzheimer's disease, augmenting acetylcholine
levels by preventing neurotransmitter degradation and reducing Aβ
aggregation, thereby simultaneously treating both the symptoms and
progression of Alzheimer's disease.